Proteolysis of Pericellular Matrix
نویسندگان
چکیده
منابع مشابه
Targeting pericellular proteolysis in vascular disease.
Proteolytic enzymes released from smooth muscle cells (SMCs) degrade extracellular matrix proteins, and this is thought to facilitate cell migration and neointimal thickening in restenosis and vein graft disease. The plasminogen activator (PA) and the matrix metalloproteinase (MMP) systems play important roles mediating these processes. In the PA system, tissue-type plasminogen activator (t-PA)...
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Malignant cells are characterized by high mitogenic activity, disorganized growth, and the ability to invade surrounding normal tissues in vivo. Invasion and metastasis require the release of cells from the restrictive effects of the extracellular matrix, the degradation of basement membranes, the intrusion of malignant cells into connective tissues, and their spread through circulation or lymp...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2004
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000149753.74793.88